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English(EN) 🔬ESMFold2: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

BioHub发布ESMFold 2,以规模化Transformer模型挑战AlphaFold

BioHub发布了ESMFold 2,这是一个用于蛋白质生物学的开放科学引擎,利用在海量蛋白质序列数据上训练的Transformer模型。该新模型在预测蛋白质相互作用方面,尤其是在抗体方面,展现了最先进的性能,并在癌症和免疫学研究中显示出希望。ESMFold 2的方法依赖于规模法则和无监督学习,而不是像AlphaFold这样的模型所使用的传统多序列比对,这预示着蛋白质结构预测方法论的潜在转变。 AI

影响 挑战AlphaFold等现有蛋白质折叠模型,可能通过规模化的Transformer架构加速药物发现和治疗开发。

排序理由 发布了一个新的科学模型和相关论文,展示了最先进的性能。

在 Latent Space (swyx) 阅读 →

AI 生成摘要 · Google Gemini · 来自 2 个来源。 我们如何撰写摘要 →

BioHub发布ESMFold 2,以规模化Transformer模型挑战AlphaFold

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发布了一个新的科学模型和相关论文,展示了最先进的性能。
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报道来源 [2]

  1. Latent Space (swyx) TIER_1 English(EN) · RJ Honicky ·

    🔬ESMFold2:蛋白质的苦涩教训即将来临 - Alex Rives, BioHub

    Datasets vs. inductive bias, world models, and programmable biology

  2. Latent Space (podcast video) TIER_1 English(EN) · Latent Space ·

    🔬 苦涩的教训即将降临蛋白质 - Alex Rives, BioHub

    Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “ne…