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English(EN) MUSS: A Multi-scale and Sequence-based Model for Single-cell Gene Regulation

新型MUSS模型增强单细胞基因调控分析

研究人员开发了MUSS,这是一种新颖的多尺度和基于序列的模型,旨在改善对单细胞基因调控的理解。该模型整合了DNA序列信息与染色质可及性和基因表达数据,同时保留了DNA层面和细胞层面的分辨率。MUSS在各种任务中表现出色,包括基因表达预测和细胞聚类,其性能优于现有的基线模型。 AI

影响 该模型有望通过提供对细胞层面基因调控更细致的理解来推动生物学研究。

排序理由 该集群描述了一篇关于特定科学领域新颖模型的最新研究论文。[lever_c_demoted from research: ic=1 ai=1.0]

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新型MUSS模型增强单细胞基因调控分析

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该集群描述了一篇关于特定科学领域新颖模型的最新研究论文。[lever_c_demoted from research: ic=1 ai=1.0]
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报道来源 [1]

  1. arXiv cs.AI TIER_1 English(EN) · Kangjie Zheng, Amirhossein Vahidi, Liying Jin, Joseph Clarke, Vijaya Baskar MS, Connor Rogerson, Mengji Zhang, Muzlifah Haniffa, Anshul Kundaje, Mo Lotfollahi ·

    MUSS:一种用于单细胞基因调控的多尺度和基于序列的模型

    arXiv:2611.08086v1 Announce Type: new Abstract: Modeling gene regulation in single cells requires jointly representing DNA sequence, chromatin accessibility, and gene expression across regulatory scales. Sequence-based models capture DNA-level regulatory grammar but often lack ce…