English(EN) Locality-Controlled Out-of-Distribution Guidance for Robust Regulatory DNA Sequence Design

新的DNA序列设计方法LOCOGEN保护基序，提高鲁棒性

作者 PulseAugur 编辑部 · [1 个来源] · 2026-11-02 05:00

研究人员开发了LOCOGEN，一种用于设计具有改进鲁棒性和特异性的监管DNA序列的新方法。与先前将引导视为均匀幅度调整的方法不同，LOCOGEN认识到DNA语法的空间非均匀性。它保护关键基序位置免受扰动，同时允许在背景区域进行更多探索，从而更好地满足属性、新颖性和合理性目标。该方法在采样时作用于冻结的扩散模型骨干，无需重新训练。 AI

影响该方法可能带来更精确可靠的基因编辑工具和合成生物学应用。

排序理由该条目是发表在arXiv上的研究论文，详细介绍了一种新的DNA序列设计方法。[lever_c_demoted from research: ic=1 ai=1.0]

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arXiv cs.LG TIER_1 English(EN) · Dabin Jeong, Marwane Bourdim, Mo Lotfollahi · 2026-11-02 05:00

Locality-Controlled Out-of-Distribution Guidance for Robust Regulatory DNA Sequence Design

arXiv:2610.41736v1 Announce Type: new Abstract: Designing regulatory DNA sequences for targeted gene-expression control is an important challenge. Recent approaches frame this task as property-conditioned generation, where diffusion models trained on natural sequences are guided …

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Locality-Controlled Out-of-Distribution Guidance for Robust Regulatory DNA Sequence Design

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