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English(EN) Human genetic evidence is associated with drug approval across therapeutic areas: an observational analysis of 26,278 target-disease pairs with temporal validation and feature ablation

研究发现遗传证据与药物批准率密切相关

一项对 26,278 个靶点-疾病对进行的新的观察性分析发现,与没有遗传关联的药物靶点相比,具有遗传关联的药物靶点的批准率显著更高。该研究利用了 Open TargetsChEMBL 的数据,表明遗传相关靶点的批准率高出 3.25 倍。虽然文献挖掘占了分类器性能的大部分,这可能表明存在来自批准后出版物的潜在时间泄露,但其他证据类型仍然保留了基线信号。该研究还确定了 1,433 个遗传支持的 Phase 1/2 对,可作为生成假设的资源,尽管分类器的实际预测价值被认为有限。 AI

排序理由 该集群包含一篇在 arXiv 上发表的学术论文,详细介绍了研究结果。[lever_c_demoted from research: ic=1 ai=0.1]

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  1. arXiv cs.AI TIER_1 English(EN) · Victoria Paterson ·

    Human genetic evidence is associated with drug approval across therapeutic areas: an observational analysis of 26,278 target-disease pairs with temporal validation and feature ablation

    arXiv:2606.14823v1 Announce Type: cross Abstract: Genetic evidence is enriched among approved drug targets: in an observational analysis of 26,278 target-disease pairs from Open Targets and ChEMBL, targets with any genetic association had a 3.25-fold higher approval rate than tho…