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English(EN) Scalable Agentic Reasoning for Designing Biologics Targeting Intrinsically Disordered Proteins

AI代理为难靶点设计生物制品

研究人员开发了StructBioReasoner,这是一个多代理系统,旨在应对设计靶向无序蛋白(IDPs)的生物制品的挑战,由于其缺乏稳定的结构,IDPs难以靶向。该系统利用基于锦标赛的推理框架,其中专业代理进行协作,整合各种计算工具,如AI结构预测和分子模拟。在Der f 21和NMNAT-2蛋白上的基准测试表明,超过一半的设计候选者优于现有结合剂,证明了该系统在Exascale平台上推进治疗性发现的潜力。 AI

影响 该代理推理系统可以加速为具有挑战性的治疗靶点设计新型生物制品。

排序理由 这是一篇详细介绍用于药物发现的新计算系统的研究论文。

在 arXiv cs.AI 阅读 →

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AI代理为难靶点设计生物制品

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这是一篇详细介绍用于药物发现的新计算系统的研究论文。
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报道来源 [1]

  1. arXiv cs.AI TIER_1 English(EN) · Matthew Sinclair, Moeen Meigooni, Archit Vasan, Ozan Gokdemir, Xinran Lian, Heng Ma, Yadu Babuji, Alexander Brace, Khalid Hossain, Carlo Siebenschuh, Thomas Brettin, Kyle Chard, Christopher Henry, Venkatram Vishwanath, Rick L. Stevens, Ian T. Foster, Arvi ·

    可扩展的代理推理用于设计靶向无序蛋白的生物制品

    arXiv:2512.15930v2 Announce Type: replace-cross Abstract: Intrinsically disordered proteins (IDPs) represent crucial therapeutic targets due to their significant role in disease -- approximately 80\% of cancer-related proteins contain long disordered regions -- but their lack of …