English(EN) REFLEX: RNA Ensemble Generation via Flexibility-Calibrated Stochastic Bridge

新的REFLEX方法以高保真度生成多样化的RNA集合

作者 PulseAugur 编辑部 · [1 个来源] · 2026-10-23 04:00

研究人员开发了REFLEX，一种新的RNA集合生成方法，能够准确捕捉多样化的构象状态，而不会塌缩为平均结构或漂移到不支持的区域。这种序列条件生成器在SE(3)上使用异方差随机桥接，在训练期间通过实验B-因子进行校准，以调整局部扰动尺度。在推理时，REFLEX仅依赖于输入序列，在多构象RNA基准测试中，在集合覆盖率方面表现出优越的精确率-召回率权衡。 AI

影响该方法通过改进RNA结构和功能的建模，有望推动计算生物学和药物发现的发展。

排序理由该条目是一篇研究论文，详细介绍了一种新的RNA集合生成方法，发表在arXiv上。[lever_c_demoted from research: ic=1 ai=1.0]

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arXiv cs.AI TIER_1 English(EN) · Wanli Ma, Tianmeng Hu, Ke Li · 2026-10-23 04:00

REFLEX: RNA Ensemble Generation via Flexibility-Calibrated Stochastic Bridge

arXiv:2610.26261v3 Announce Type: replace Abstract: RNA molecules often function through multiple experimentally observed conformational states. A central challenge is to capture ensemble diversity without sacrificing structural fidelity: samples may collapse toward averaged repr…

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REFLEX: RNA Ensemble Generation via Flexibility-Calibrated Stochastic Bridge

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