English(EN) Human mutation field reveals an equilibrium-like structure with irreversible circulation

人类突变场显示出类平衡结构和残余非平衡循环

作者 PulseAugur 编辑部 · [1 个来源] · 2026-09-10 04:00

研究人员在人类突变场中发现了一种类平衡结构，表明DNA序列演化在很大程度上可以用能量景观上的随机动力学来描述。他们使用Siamese神经网络对突变概率进行建模，发现与经验数据高度相关，表明大多数突变偏差与这种推断的景观一致。然而，发现了一个微小但可检测到的非平衡成分，揭示了违反详细平衡的Kolmogorov循环条件的特定定向突变机制。 AI

影响这项研究提供了突变偏差的热力学分解，可能为未来的基因组分析和演化过程的理解提供信息。

排序理由学术论文，详细介绍了定量生物学的新发现。[lever_c_demoted from research: ic=1 ai=0.4]

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报道来源 [1]

arXiv cs.AI TIER_1 English(EN) · Isabella Caranzano, Daniel Maria Busiello, Stefano Priorelli, Amos Maritan, Piero Fariselli · 2026-09-10 04:00

人类突变场揭示具有不可逆循环的类平衡结构

arXiv:2609.07500v1 Announce Type: cross Abstract: The evolution of DNA sequences can be viewed as stochastic dynamics on a high-dimensional discrete space, but it is unclear when empirical transition biases reduce to an effective energy landscape versus retain irreducible non-equ…

本文如何被排名

报道来源 [1]

人类突变场揭示具有不可逆循环的类平衡结构

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