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AI system ImmuneAgent accelerates discovery of broadly neutralizing antibodies

Researchers have developed ImmuneAgent, an AI system designed to discover broadly neutralizing antibodies (bnAbs) from human B cell repertoires. This system integrates multimodal reasoning with continual meta-learning and incorporates wet-lab feedback to address challenges like the rarity of bnAbs and the generalization across different viruses. In tests, ImmuneAgent achieved a significant antibody discovery rate and a notable bnAb yield, outperforming existing computational methods. The discovered antibodies demonstrated efficacy in protecting against influenza and identified key cellular and structural determinants of antibody activity, which generalized to new antigens like human metapneumovirus and human papillomavirus. AI

IMPACT Accelerates therapeutic antibody discovery against emerging viral threats by improving efficiency and generalization.

RANK_REASON The cluster contains a research paper detailing a new AI system for antibody discovery. [lever_c_demoted from research: ic=1 ai=1.0]

Read on arXiv cs.AI →

AI-generated summary · Google Gemini · from 1 sources. How we write summaries →

AI system ImmuneAgent accelerates discovery of broadly neutralizing antibodies

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The cluster contains a research paper detailing a new AI system for antibody discovery. [lever_c_demoted from research: ic=1 ai=1.0]
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COVERAGE [1]

  1. arXiv cs.AI TIER_1 English(EN) · Hantao Lou, Jianqing Zheng, Can Yue, Meihan Zhang, Yuanchao Bao, Yu Chen, Mengting Huang, Yupeng Yang, Qianyu Pan, Nana Fu, Yansong Shi, Hongli Li, Yangyang Chai, Ruyi Chen, Wansheng Li, Zhu Liang, Rongmei Yao, Yuanhan Mo, Lei Wang, Chunmei Wang, Yun Qua… ·

    Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families

    arXiv:2610.03160v1 Announce Type: cross Abstract: Discovering broadly neutralizing antibodies (bnAbs) from human natural immune repertoires remains a fundamental challenge in immunology, hindered by: the extreme rarity of bnAb, incomplete understanding of their cellular origins a…