Boltz, a company specializing in structural biology AI, has released open-source models Boltz-1 and Boltz-2, advancing beyond single-chain protein prediction to complex interactions and generative design. These models leverage generative diffusion approaches and specialized equivariant architectures, moving beyond simple regression to better handle uncertainty and multiple conformational states. Boltz-2 specifically focuses on predicting binding affinity and can generate novel protein sequences and structures based on high-level specifications, with significant success in lab validation. AI
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RANK_REASON Release of open-source AI models for drug discovery, building on prior research like AlphaFold.
