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LLMs enhanced for cancer survival prediction with reasoning framework

Researchers have developed a new framework called OncoReason to improve the interpretability and accuracy of large language models (LLMs) in predicting cancer treatment outcomes. This multi-task learning approach trains LLMs to perform survival classification, time regression, and generate natural language rationales for their predictions. Experiments using LLaMa3-8B and Med42-8B models showed that Chain-of-Thought prompting and Group Relative Policy Optimization significantly enhanced predictive performance and interpretability, setting a new benchmark for trustworthy LLMs in oncology. AI

IMPACT Enhances LLM interpretability and accuracy for clinical decision support, potentially improving patient outcomes.

RANK_REASON The cluster contains a research paper detailing a new framework and methodology for LLMs in a specific domain. [lever_c_demoted from research: ic=1 ai=1.0]

Read on arXiv cs.CL →

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COVERAGE [1]

  1. arXiv cs.CL TIER_1 English(EN) · Raghu Vamshi Hemadri, Geetha Krishna Guruju, Kristi Topollai, Anna Ewa Choromanska ·

    OncoReason: Structuring Clinical Reasoning in LLMs for Robust and Interpretable Survival Prediction

    arXiv:2510.17532v2 Announce Type: replace Abstract: Predicting cancer treatment outcomes requires models that are both accurate and interpretable, particularly in the presence of heterogeneous clinical data. While large language models (LLMs) have shown strong performance in biom…