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Protein language models show depth inefficiency similar to LLMs

Researchers have investigated the "Curse of Depth" phenomenon in protein language models (PLMs), finding that, similar to large language models, many layers in PLMs contribute minimally to final predictions. This study analyzed seven popular PLM families, examining autoregressive, masked, and diffusion objectives across various scales. The findings indicate that a significant portion of task-relevant computation is concentrated in specific layers, with others offering only incremental improvements, a trend observed even in multimodal PLMs. AI

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IMPACT Suggests potential for more efficient protein language model architectures and training methods.

RANK_REASON Academic paper analyzing a phenomenon in protein language models.

Read on arXiv cs.LG →

COVERAGE [1]

  1. arXiv cs.LG TIER_1 · Aleena Siji, Amir Mohammad Karimi Mamaghan, Ferdinand Kapl, Tobias H\"oppe, Emmanouil Angelis, Andrea Dittadi, Maurice Brenner, Michael Heinzinger, Karl Henrik Johansson, Kaitlin Maile, Johannes von Oswald, Stefan Bauer ·

    From Words to Amino Acids: Does the Curse of Depth Persist?

    arXiv:2602.21750v2 Announce Type: replace Abstract: Protein language models (PLMs) have become widely adopted as general-purpose models, demonstrating strong performance in protein engineering and de novo design. Like large language models (LLMs), they are typically trained as de…