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RiboBridge framework designs RNA binders for protein structures

By PulseAugur Editorial · [2 sources] ·

Researchers have developed RiboBridge, a novel framework for designing RNA molecules that can bind to specific protein structures. This structure-first approach separates the generation of RNA conformations from the assembly of the protein-RNA complex. RiboBridge first identifies potential binding interfaces on the protein, then generates RNA conformations using a pretrained latent space called RiboSphere, and finally predicts interaction constraints to align the two components. AI

IMPACT This framework could accelerate the design of new RNA-based therapeutics and molecular tools by improving the accuracy and efficiency of protein-RNA binding predictions.

RANK_REASON The cluster describes a new research paper detailing a novel computational framework for a scientific problem.

Read on Hugging Face Daily Papers →

AI-generated summary · Google Gemini · from 2 sources. How we write summaries →

RiboBridge framework designs RNA binders for protein structures

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COVERAGE [2]

  1. arXiv cs.LG TIER_1 English(EN) · Zhou Zhang, Hanqun Cao, Minghao Sun, Odin Zhang, Yang Zhang, Pheng Ann Heng, Wujun Li, Tianfan Fu ·

    RiboBridge: protein-conditioned de novo RNA binder structure design

    arXiv:2610.30668v1 Announce Type: new Abstract: Designing RNA molecules that bind to target protein structures requires generating both an RNA conformation and its bound complex geometry, without assuming a predefined binding site. Existing approaches generally model these couple…

  2. Hugging Face Daily Papers TIER_1 English(EN) ·

    RiboBridge: protein-conditioned de novo RNA binder structure design

    Designing RNA molecules that bind to target protein structures requires generating both an RNA conformation and its bound complex geometry, without assuming a predefined binding site. Existing approaches generally model these coupled processes within a unified representation, ent…

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