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Scientists engineer mice to produce own antibodies for extended treatment

Researchers have developed a novel method to enable the body to produce its own antibodies for extended periods, addressing the limitations of current antibody drugs. This technique involves gene-editing blood-forming stem cells to carry a blueprint for a specific antibody, which then act as a continuous factory within the body. The edited cells can be triggered by a vaccine booster to produce high levels of the chosen antibody, showing promising results in mice against HIV, malaria, and influenza, and even enabling the production of multiple antibodies simultaneously. AI

IMPACT This research could lead to more effective and cost-efficient long-term treatments for chronic diseases and infections.

RANK_REASON The cluster describes a scientific study published in a journal detailing a new method for antibody production. [lever_c_demoted from research: ic=1 ai=0.4]

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Scientists engineer mice to produce own antibodies for extended treatment

COVERAGE [1]

  1. Forbes — Innovation TIER_1 English(EN) · William A. Haseltine, Contributor ·

    Teaching Your Body To Make Designer Antibodies

    Editing a small number of blood-forming stem cells to encode powerful antibodies turns the immune system into a living drug factory.