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ProTok Unifies Protein Sequence, Structure, and Function into Single Tokenizer

Researchers have developed ProTok, a novel protein tokenizer that unifies protein sequence, structure, and functional annotations into a single discrete vocabulary. This modular approach uses product quantization with modality dropout, allowing for flexible inference from any subset of modalities without retraining. ProTok demonstrates strong performance on benchmarks, achieving high reconstruction accuracy and leading in zero-shot functional retrieval. It also enables joint generation of backbone and sequence, outperforming existing baselines. AI

IMPACT This research could lead to more expressive protein language models by enabling them to reason over a unified token stream representing sequence, structure, and function.

RANK_REASON The item describes a new research paper detailing a novel method for protein tokenization. [lever_c_demoted from research: ic=1 ai=1.0]

Read on Hugging Face Daily Papers →

AI-generated summary · Google Gemini · from 1 sources. How we write summaries →

ProTok Unifies Protein Sequence, Structure, and Function into Single Tokenizer

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The item describes a new research paper detailing a novel method for protein tokenization. [lever_c_demoted from research: ic=1 ai=1.0]
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  1. Hugging Face Daily Papers TIER_1 English(EN) ·

    ProTok: Unified Protein Tokenization via Modular Multi-Codebook Quantization

    Protein sequence, structure, and functional annotations each capture complementary aspects of protein biology, yet existing tokenizers encode each modality independently, limiting the expressiveness of discrete protein representations. We present ProTok, a unified protein tokeniz…