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New research explores LLM evaluation and application in clinical medicine · 8 sources tracked

Multiple research papers are exploring the evaluation and application of large language models (LLMs) in clinical settings. One paper introduces STEP-CTS, a method for selecting source-traceable evidence for LLM predictions from clinical time series, outperforming existing text-based baselines. Another paper reviews existing rubrics for evaluating clinical reasoning in LLMs, identifying gaps in areas like temporal synthesis and faithfulness. Additionally, research is investigating bias in open-source LLMs for clinical triage, developing multimodal LLMs for medical image reasoning, and creating benchmarks like KlinikeBench to assess LLMs beyond simple diagnostic accuracy. The broader application of LLMs in clinical medicine, including their reliability and safety, is also a growing area of focus. AI

IMPACT These studies highlight the growing need for robust evaluation frameworks and specialized models for safe and effective LLM deployment in healthcare.

RANK_REASON Multiple arXiv papers introducing new benchmarks, methods, and analyses for LLMs in clinical settings.

Read on arXiv cs.AI →

AI-generated summary · Google Gemini · from 8 sources. How we write summaries →

New research explores LLM evaluation and application in clinical medicine · 8 sources tracked

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Multiple arXiv papers introducing new benchmarks, methods, and analyses for LLMs in clinical settings.
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paper, product, safety
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COVERAGE [8]

  1. arXiv cs.LG TIER_1 English(EN) · Kwanhyung Lee, Juhwan Choi, Jongheon Kim, Joohyung Lee, Hyeongwon Jang, Jeonguk Lee, Jisoo Jung, Eunho Yang ·

    Learning to Select Source-Traceable Evidence for Language-Model Prediction from Irregular Clinical Time Series

    arXiv:2605.20292v2 Announce Type: replace Abstract: Numerical time-series models effectively process irregular electronic health record (EHR) trajectories, but do not expose which temporal patterns support each prediction as readable evidence. Existing text-based interfaces eithe…

  2. arXiv cs.AI TIER_1 English(EN) · Zhangshu Joshua Jiang, Zina Ibrahim, James T. Teo ·

    A rubric landscape for evaluating clinical reasoning in large language models: what exists, what is missing, and what needs to be combined

    arXiv:2610.01938v1 Announce Type: cross Abstract: Exam-style accuracy does not establish whether large language models (LLMs) reason well over clinical records. We define clinical reasoning as integrating and updating evidence across time and sources to form, revise and justify a…

  3. arXiv cs.AI TIER_1 English(EN) · Manar Aljohani, Brandon Ho, Kenneth McKinley, Dennis Ren, Xuan Wang ·

    Counterfactual Auditing of Bias in Open-Source Large Language Models for Clinical Triage

    arXiv:2610.01963v1 Announce Type: new Abstract: Emergency department (ED) triage is a high-stakes prioritization task in which demographic, socioeconomic, and system-context information may improperly influence acuity assignment. Although open-source large language models (LLMs) …

  4. arXiv cs.AI TIER_1 English(EN) · Zhen Chen, Yihang Fu, Rong Zhou, Serina Applebaum, Min Kyu Kim, Aidan Gilson, Morten Lee, Salahudeen Mirza, Gabriel Madera, Mauro Giuffre, Yuanting Pan, Roy Jiang, Hyunjae Kim, Hua Xu, Qingyu Chen ·

    From Compound Figures to Medical Multi-image Reasoning: Scaling Multimodal Large Language Models with Biomedical Literature

    arXiv:2511.22232v2 Announce Type: replace-cross Abstract: Multimodal large language models (MLLMs) are increasingly capable in medical imaging, yet most focus on single-image settings. Clinical interpretation often requires integrating evidence across multiple images, such as dif…

  5. arXiv cs.AI TIER_1 English(EN) · Xueting Fang, Zehui Li, Yang Yang, Camilla Giovino, Shubh K. Patel, Shailly Prajapati, Vallijah Subasri, Caihua Shan ·

    KlinikeBench: Evaluating Language Models Beyond Diagnostic Accuracy

    arXiv:2609.38480v1 Announce Type: cross Abstract: Most clinical benchmarks evaluate language models (LMs) on diagnosis using complete case descriptions. In clinical practice, however, patients present information in different ways, and clinicians must obtain relevant history and …

  6. arXiv cs.AI TIER_1 English(EN) · Naoto Iwase, Hiroki Okuyama, Junichiro Iwasawa ·

    MedRECT: A Bilingual Medical Reasoning Benchmark for Error Correction in Clinical Texts

    arXiv:2511.00421v2 Announce Type: replace-cross Abstract: Large language models (LLMs) show promise in medical applications, but their ability to detect and correct errors in clinical texts remains under-evaluated, particularly beyond English. We introduce MedRECT, a bilingual be…

  7. arXiv cs.AI TIER_1 English(EN) · Zhangshu Joshua Jiang, Zina Ibrahim, James T. Teo ·

    A Proposed Rubric for Evaluating Expressed Clinical Reasoning in Large Language Model Responses

    arXiv:2609.37788v1 Announce Type: cross Abstract: Rubrics support the structured evaluation of language models. We propose a rubric for assessing expressed clinical reasoning in model responses, drawing on three bodies of work: medical education assessment frameworks (ART, SCT, K…

  8. arXiv cs.AI TIER_1 English(EN) · Erik Aerts ·

    Applying Language Models in Clinical Medicine: Recent Trends and Perspectives

    arXiv:2609.34780v2 Announce Type: replace Abstract: The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the literature over recent years. The emergence of large language models (LLMs) has expande…