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New Asclepius agent scaffolding improves long-horizon clinical LLM performance

Researchers have developed Asclepius, a novel adaptive agent scaffolding designed to improve the performance of LLM agents in long-horizon clinical scenarios. Unlike agents typically evaluated on short tasks, Asclepius is tested on a simulated emergency department shift, revealing execution gaps in delivering complete and timely critical actions. The system addresses three failure modes: instruction-adherence drift, treatment incompleteness, and a severity-equity gap in timeliness. Asclepius incorporates a self-evolving harness, an externalized clinical skills library, and partitioned subagents, leading to a 22% improvement in critical-action correctness and a 13% gain in timeliness on held-out data. AI

IMPACT This research could lead to more robust and reliable AI agents in complex, real-world environments like healthcare, improving critical task execution and timeliness.

RANK_REASON The cluster describes a new research paper detailing a novel agent scaffolding for LLMs. [lever_c_demoted from research: ic=1 ai=1.0]

Read on arXiv cs.AI →

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New Asclepius agent scaffolding improves long-horizon clinical LLM performance

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The cluster describes a new research paper detailing a novel agent scaffolding for LLMs. [lever_c_demoted from research: ic=1 ai=1.0]
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COVERAGE [1]

  1. arXiv cs.AI TIER_1 English(EN) · Grace Chang Yuan, Xiaoman Zhang, Sung Eun Kim, Luyang Luo, Pranav Rajpurkar ·

    Asclepius: An Adaptive Harness for Long-Horizon Clinical Agents

    arXiv:2609.13543v1 Announce Type: new Abstract: LLM agents are predominantly benchmarked on short, single-task trajectories, yet real deployments run for hours under contention, surfacing a different class of failures. We use the Clinical Environment Simulator (CES), in which an …