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Donated livers made biologically younger via machine perfusion

Scientists have discovered that donated livers placed on machine perfusion systems appear to become biologically younger. Using epigenetic and gene expression "aging clocks," researchers found that livers undergoing perfusion, even if chronologically older, showed a lower biological age compared to those stored on ice. This effect, which suggests perfusion reverses biological aging by about 30%, may explain why perfused organs perform better post-transplantation and could lead to improved organ utilization and repair strategies. AI

RANK_REASON Research finding on biological aging of organs. [lever_c_demoted from research: ic=1 ai=0.0]

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Donated livers made biologically younger via machine perfusion

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Research finding on biological aging of organs. [lever_c_demoted from research: ic=1 ai=0.0]
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COVERAGE [1]

  1. MIT Technology Review TIER_1 English(EN) · Jessica Hamzelou ·

    Donated livers can be made biologically younger

    Once an organ is removed from a donor’s body, the clock starts ticking. Surgeons usually flush the organ with a preservative solution, bag it, and put it on ice—where it immediately starts to degrade. The team has a matter of hours to get it into a recipient’s body. There’s anoth…