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Clinician input steers AI toward accurate and harmful medical recommendations

A new study published on arXiv investigated how clinician input influences the recommendations of large language models (LLMs) in clinical settings. Researchers found that clinician reasoning significantly increased the accuracy of AI-generated differential diagnoses and recommendations, but also amplified harmful suggestions when the input was misleading. The study tested eight different AI models, including GPT-5, Claude Sonnet 4.5, and Gemini 3 Flash, using curated medical case records. Findings suggest that while expert clinician input improves AI performance, adversarial input poses a vulnerability that requires mitigation strategies, such as inference-time prompting, to ensure safety and robustness. AI

IMPACT Highlights the critical need for robust safety measures and evaluation metrics for LLMs in healthcare, as clinician interaction can both improve and degrade AI performance.

RANK_REASON Research paper detailing AI model behavior in a specific domain. [lever_c_demoted from research: ic=1 ai=1.0]

Read on arXiv cs.LG →

AI-generated summary · Google Gemini · from 1 sources. How we write summaries →

Clinician input steers AI toward accurate and harmful medical recommendations

COVERAGE [1]

  1. arXiv cs.LG TIER_1 English(EN) · Ivan Lopez, Selin S. Everett, Bryan J. Bunning, April S. Liang, Dong Han Yao, Shivam C. Vedak, Kameron C. Black, Sophie Ostmeier, Stephen P. Ma, Emily Alsentzer, Jonathan H. Chen, Akshay S. Chaudhari, Eric Horvitz ·

    Clinician input steers AI toward accurate and harmful recommendations

    arXiv:2603.14158v2 Announce Type: replace-cross Abstract: Large language models (LLMs) are entering clinical workflows, yet evaluations rarely assess how clinician reasoning shapes model behavior during clinical interactions. Using 61 curated NEJM Case Records, we tested how expe…