Xaira Therapeutics, led by Chief Discovery Officer Ci Chu and Chief AI Scientist Bo Wang, has developed the X-Cell model for drug discovery. This model is trained on X-Atlas, a novel dataset generated through CRISPR-based experiments that allow for parallel testing of gene expression changes. Unlike previous models that focused on RNA expression, X-Cell aims to predict the effects of altering specific genes, a crucial step for developing targeted drugs or gene therapies. The team shifted from autoregressive models to diffusion models for X-Cell and has demonstrated its ability to generalize to real-world cell experiments, outperforming existing linear baselines. AI
IMPACT This development could accelerate AI-driven drug discovery by enabling more precise prediction of gene expression changes.
RANK_REASON The cluster describes a new model and dataset for drug discovery, which falls under research.
Read on Latent Space (podcast video) →
- Bo Wang
- Chan Zuckerberg Institute
- Ci Chu
- scGPT
- Xaira Therapeutics
- X-Atlas
- X-Cell
- CRISPR
- Latent Space
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