An Uncertainty Estimation Framework for Dose Accumulation in Adaptive Radiotherapy: Application to CBCT-Guided Radiotherapy for Cervical Cancer
Researchers have developed IMPACT-DoseAcc, a new framework for estimating cumulative radiation dose in adaptive radiotherapy (ART) for cervical cancer. This system quantifies uncertainties arising from image registration and segmentation, providing probabilistic dose-volume histograms. The framework demonstrated strong correlation between registration uncertainty and geometric error, achieving high coverage for target volumes and stabilizing dose estimates. AI
IMPACT Improves interpretation of cumulative dose in ART, supporting more reproducible and uncertainty-informed treatment workflows.