🧠📐 Kaltenecker et al present # MouseMapper , that combines whole-body tissue clearing, # lightsheet # imaging and foundation-model-based # DeepLearning to quant
Researchers have developed MouseMapper, a novel system that integrates whole-body tissue clearing, lightsheet imaging, and deep learning to map cellular structures across entire mouse bodies. This technique was applied to study diet-induced obesity, revealing significant reductions in nerve density and defects in whisker-sensing nerves. The study also identified widespread inflammatory immune cell clustering in obese mice. AI
IMPACT This new imaging and AI-driven analysis technique could accelerate biological research by providing unprecedented detail on cellular structures and their relation to disease.